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Guanosine 5'-triphosphate-5'-adenosine

Names

[ CAS No. ]:
10527-47-6

[ Name ]:
Guanosine 5'-triphosphate-5'-adenosine

Biological Activity

[Description]:

Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Guanosine 5'-triphosphate-5'-adenosine (GpppA) labeled with pyrene at the 3′‐O position of adenosine acted as an artificial substrate[1]. Fluorescently labeled Guanosine 5'-triphosphate-5'-adenosine (GpppA) and GpppG analogs as potential substrates that represent a reasonable compromise between the structural complexity and requirements of the enzyme[1].

[References]

[1]. Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26(49):11266-11275.

[2]. Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12(12):4383-4388.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H27N10O17P3

[ Molecular Weight ]:
772.41

Related Compounds