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Aloeresin D

Names

[ CAS No. ]:
105317-67-7

[ Name ]:
Aloeresin D

[Synonym ]:
(1S)-1,5-Anhydro-2-O-[(2E)-3-(4-hydroxyphenyl)-2-propenoyl]-1-{2-[(2R)-2-hydroxypropyl]-7-methoxy-5-methyl-4-oxo-4H-chromen-8-yl}-D-glucitol
D-Glucitol, 1,5-anhydro-2-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-1-C-[2-[(2R)-2-hydroxypropyl]-7-methoxy-5-methyl-4-oxo-4H-1-benzopyran-8-yl]-, (1S)-

Biological Activity

[Description]:

Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC50 of 39 μM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[References]

[1]. Lv L, et al. BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis. Planta Med. 2008 Apr;74(5):540-5.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
796.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H32O11

[ Molecular Weight ]:
556.558

[ Flash Point ]:
261.7±26.4 °C

[ Exact Mass ]:
556.194458

[ PSA ]:
176.12000

[ LogP ]:
2.98

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.659

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds