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Tanshinlactone

Names

[ CAS No. ]:
105351-70-0

[ Name ]:
Tanshinlactone

[Synonym ]:
Tanshinlactone
10H-Furo[3,2-b]naphtho[2,1-d]pyran-10-one, 1,6-dimethyl-
1,6-Dimethyl-10H-benzo[h]furo[3,2-c]isochromen-10-one

Biological Activity

[Description]:

Tanshinlactone is a seco-abietanoid that can be isolated from Salvia miltiorrhiza. Tanshinlactone is a coronavirus (CoV) inhibitor. Tanshinlactone modulates interleukin-2 and interferon-γ gene expression[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Rodrigues GCS, et a;. Ligand and Structure-based Virtual Screening of Lamiaceae Diterpenes with Potential Activity against a Novel Coronavirus (2019-nCoV). Curr Top Med Chem. 2020;20(24):2126-2145.  

[2]. Wu MH, et al. Tanshinlactone A from Salvia miltiorrhiza modulates interleukin-2 and interferon-gamma gene expression. J Ethnopharmacol. 2007 Sep 5;113(2):210-7.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
459.0±24.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H12O3

[ Molecular Weight ]:
264.275

[ Flash Point ]:
231.4±22.9 °C

[ Exact Mass ]:
264.078644

[ PSA ]:
43.35000

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.664

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds