RS 8359

Names

[ Name ]:
RS 8359

[Synonym ]:
Benzonitrile, 4-[(6,7-dihydro-7-hydroxy-5H-cyclopenta[d]pyrimidin-4-yl)amino]-
4-[(7-Hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino]benzonitrile
UNII:79U9T1HIX9
RS 8359

Biological Activity

[Description]:

RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[In Vivo]

RS 8359 shows relatively little effect upon blood pressure when administered together with tyramine. RS-8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect[1].

[References]

[1]. Iwata N, et al. Pharmacology of the new reversible inhibitor of monoamine oxidase A, RS-8359. Int Clin Psychopharmacol. 1997 Sep;12 Suppl 5:S3-10.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
483.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂N₄O

[ Molecular Weight ]:
252.271

[ Flash Point ]:
246.3±28.7 °C

[ Exact Mass ]:
252.101105

[ PSA ]:
81.83000

[ LogP ]:
1.12

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.682

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%