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LY 345899

Names

[ CAS No. ]:
10538-99-5

[ Name ]:
LY 345899

Biological Activity

[Description]:

LY 345899 is a human cytosolic methylenetetrahydrofolate dehydrogenase/cyclohydrolase (DC301) inhibitor, with a Ki of 0.018 μM.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

Ki: 0.018 μM (DC301)[1].


[References]

[1]. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21N7O7

[ Molecular Weight ]:
471.42

[ Storage condition ]:
2-8℃

Related Compounds