Radafaxine (hydrochloride)

Names

[ Name ]:
Radafaxine (hydrochloride)

[Synonym ]:
(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride
Radafaxine (hydrochloride)

Biological Activity

[Description]:

Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter

Research Areas >> Neurological Disease

[References]

[1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70.

[2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93.

[Related Small Molecules]

Reserpine | NBI-98782 | (±)-Tetrabenazine | Vanilpyruvic acid

Chemical & Physical Properties

[ Density]:
1.144g/cm3

[ Boiling Point ]:
386.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₉Cl₂NO₂

[ Molecular Weight ]:
292.20100

[ Flash Point ]:
187.6ºC

[ Exact Mass ]:
291.07900

[ PSA ]:
41.49000

[ LogP ]:
3.40280

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%