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DMT1 blocker 2

Names

[ CAS No. ]:
1062648-63-8

[ Name ]:
DMT1 blocker 2

Biological Activity

[Description]:

DMT1 blocker 2, Compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 of 0.83 μM, is expected to block iron uptake by enterocytes in vivo[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

IC50: 0.83 μM (DMT1 blocker 2)[1]

[References]

[1]. Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H13N3O

[ Molecular Weight ]:
263.29

Related Compounds