1-(Acetyloxy)-1,2-dihydroobacunoic Acid e-Lactone

Names

[ Name ]:
1-(Acetyloxy)-1,2-dihydroobacunoic Acid e-Lactone

[Synonym ]:
fromcitrusseeds
1-(Acetyloxy)-1,2-dihydroobacunoic Acid e-Lactone
Oxireno[4',5']pyrano[4',3':5,6]naphth[2,1-c]oxepin-3,10,12(1H,4H,10aH)-trione, 5-(acetyloxy)-8-(3-furanyl)decahydro-1,1,5a,7a,11b-pentamethyl-, (5S,5aR,5bR,7aS,8S,10aS,11aR,11bR,13aR)-
(5S,5aR,5bR,7aS,8R,10aS,11aR,11bR,13aR)-8-(furan-3-yl)-1,1,5a,7a,11b-pentamethyl-3,10,12-trioxohexadecahydrooxireno[4,4a]isochromeno[6,5-g][2]benzoxepin-5-yl acetate
(5S,5aR,5bR,7aS,8S,10aS,11aR,11bR,13aR)-8-(3-Furyl)-1,1,5a,7a,11b-pentamethyl-3,10,12-trioxohexadecahydrooxireno[4,4a]isochromeno[6,5-g][2]benzoxepin-5-yl acetate
1-(3-Furyl)decahydro-11-hydroxy-4b,7,7,11a,13a-pentamethyloxireno(4,4a)-2-benzopyrano[6,5-g](2)benzoxepin-3,5,9(3aH,4bH,6H)-trione Acetate

Biological Activity

[Description]:

Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent [1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown[1].

[In Vivo]

Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5[1].

[References]

[1]. Shi YS, et al. Nomilin protects against cerebral ischemia-reperfusion induced neurological deficits and blood-brain barrier disruption via the Nrf2 pathway. Food Funct. 2019 Sep 1;10(9):5323-5332.

[2]. Sato R, et al. Nomilin as an anti-obesity and anti-hyperglycemic agent. Vitam Horm. 2013;91:425-39.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
657.7±55.0 °C at 760 mmHg

[ Melting Point ]:
278-279°

[ Molecular Formula ]:
C₂₈H₃₄O₉

[ Molecular Weight ]:
514.564

[ Flash Point ]:
351.6±31.5 °C

[ Exact Mass ]:
514.220276

[ PSA ]:
121.64000

[ LogP ]:
2.47

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.575

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Comparative metabolic and transcriptional analysis of a doubled diploid and its diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) suggests its potential value for stress resistance improvement.

BMC Plant Biol. 15 , 89, (2015)

Polyploidy has often been considered to confer plants a better adaptation to environmental stresses. Tetraploid citrus rootstocks are expected to have stronger stress tolerance than diploid. Plenty of...

Development of delayed bitterness and effect of harvest date in stored juice from two complex citrus hybrids.

J. Sci. Food Agric. 96 , 422-9, (2015)

Mandarins and mandarin hybrids have excellent flavor and color attributes, making them good candidates for consumption as fresh fruit. When processed into juice, however, they are less palatable, as t...

Evaluation of Physiological Activities of the Citron (Citrus junos Sieb. ex TANAKA) Seed Extracts.

Prev. Nutr. Food Sci. 18 , 196-202, (2014)

Citron seed extracts (CSEs) were made using distilled water (CSEW), ethanol (CSEE), and n-hexane (CSEH), to measure the total polyphenol contents, DPPH and ABTS radical scavenging activities, and anti...