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O-Butyryl timolol

Names

[ CAS No. ]:
106351-79-5

[ Name ]:
O-Butyryl timolol

[Synonym ]:
Timolol butyryl ester
Butyryl timolol
O-Butyryl timolol

Biological Activity

[Description]:

Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vitro]

Butyryltimolol, a prodrug of Timolol, is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption[1].

[References]

[1]. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69.

[2]. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9.

Chemical & Physical Properties

[ Density]:
1.169g/cm3

[ Boiling Point ]:
511.5ºC at 760 mmHg

[ Molecular Formula ]:
C17H30N4O4S

[ Molecular Weight ]:
386.51000

[ Flash Point ]:
263.2ºC

[ Exact Mass ]:
386.19900

[ PSA ]:
114.05000

[ LogP ]:
2.30940

[ Vapour Pressure ]:
1.41E-10mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
-20℃

Related Compounds