NSC 140873

Names

[ Name ]:
NSC 140873

[Synonym ]:
2-glycine amide-5-chlorophenyl 2-pyrryl ketone
GCPK

Biological Activity

[Description]:

NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

NSC 140873 (1 至 100 μM，5-6 天) 降低斑马鱼胚胎中的确定性造血功能[2]。 NSC 140873 对高表达 RUNX1 的细胞具有抗增殖活性[2]。

[References]

[1]. Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1.

[2]. Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₂ClN₃O₂

[ Molecular Weight ]:
277.71

[ Exact Mass ]:
277.06200

[ PSA ]:
91.47000

[ LogP ]:
3.14610