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Hederacolchiside A1

Names

[ CAS No. ]:
106577-39-3

[ Name ]:
Hederacolchiside A1

[Synonym ]:
(3β,5ξ,18α)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid
Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1-&gt;4)]-α-L-arabinopyranosyl]oxy]-, (3β,5ξ,18α)-

Biological Activity

[Description]:

Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

PI3K

Akt

mTOR


[In Vitro]

Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1].

[In Vivo]

hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].

[References]

[1]. Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222

[2]. Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13;23(6).

Chemical & Physical Properties

[ Density]:
1.36±0.1 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
967.2±65.0 °C at 760 mmHg

[ Melting Point ]:
253-255℃ (methanol , water )

[ Molecular Formula ]:
C47H76O16

[ Molecular Weight ]:
897.097

[ Flash Point ]:
276.2±27.8 °C

[ Exact Mass ]:
896.513306

[ LogP ]:
7.36

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Insuluble (3.9E-4 g/L) (25 ºC)

Related Compounds