KDM4-IN-3

Names

[ Name ]:
KDM4-IN-3

Biological Activity

[Description]:

KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

[References]

[1]. Carter DM, et al. Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J Med Chem. 2021 Oct 14;64(19):14266-14282.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄N₄O

[ Molecular Weight ]:
290.32

Related Compounds

kdm4-in-2
KDM4-IN-4
DUBs-IN-3
CETP-IN-3
ILK-IN-3
CD80-IN-3
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
2-({[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopent-2-en-1-yl]formamido}methyl)cyclopentane-1-carboxylic acid
(4-Methyl-tetrahydro-furan-2-yl)-methanol
1-[6-(2-Chloro-6-fluorophenyl)-5-fluoropyrimidin-4-yl]methanamine
Methyl 3-(2-chloro-5-methylphenyl)-3-oxopropanoate
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde