1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

Names

[ Name ]:
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

[Synonym ]:
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
EINECS 213-963-9
(R)-1,2-distearoylphosphatidylethanolamine zwitterion
(R)-1-((((2-Aminoethoxy)hydroxyphosphinyl)oxy)methyl)ethane-1,2-diyl distearate
octadecanoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
2-Aminoethyl (R)-2,3-Bis(octadecanoyloxy)propyl Hydrogen Phosphate
1,2-Dioctadecanoyl-sn-glycero-3-phosphoethanolamine
3-sn-Phosphatidylethanolamine
2-Ammonioethyl (2R)-2,3-bis(stearoyloxy)propyl phosphate
Octadecanoic acid, (1R)-2-[[(2-aminoethoxy)hydroxyphosphinyl]oxy]-1-[[(1-oxooctadecyl)oxy]methyl]ethyl ester
1,2-distearoyl L-β,γ-Distearoyl-α-cephalin
[3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

Biological Activity

[Description]:

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis of liposomes.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. McCarley RL, et al. Redox-responsive delivery systems. Annu Rev Anal Chem (Palo Alto Calif). 2012;5:391-411.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.996

[ Boiling Point ]:
760.2±70.0 °C at 760 mmHg

[ Melting Point ]:
172-173ºC

[ Molecular Formula ]:
C₄₁H₈₂NO₈P

[ Molecular Weight ]:
748.065

[ Flash Point ]:
413.5±35.7 °C

[ Exact Mass ]:
747.577820

[ PSA ]:
144.19000

[ LogP ]:
15.83

[ Vapour Pressure ]:
0.0±5.5 mmHg at 25°C

[ Index of Refraction ]:
1.473

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast Cancer.

Theranostics 6 , 1-13, (2016)

Lipocalin 2 (Lcn2) is a promising therapeutic target as well as a potential diagnostic biomarker for breast cancer. It has been previously shown to promote breast cancer progression by inducing the ep...

Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes.

Eur. J. Pharm. Sci. 62 , 23-32, (2014)

Drug delivery from topically instilled eye drops to the posterior segment of the eye has long been one of the greatest challenges of ocular drug development. We developed methods of liposome preparati...

A carbon nanotube-polymer composite for T-cell therapy.

Nat. Nanotechnol. 9(8) , 639-47, (2014)

Clinical translation of cell therapies requires strategies that can manufacture cells efficiently and economically. One promising way to reproducibly expand T cells for cancer therapy is by attaching ...