GK187

Names

[ Name ]:
GK187

[Synonym ]:
3-Heptanone, 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)-
1,1,1,2,2-Pentafluoro-7-(4-methoxyphenyl)-3-heptanone
GK187

Biological Activity

[Description]:

GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders[1]. [The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Neurological Disease

[Target]

XI(50): 0.0001 (GVIA iPLA2)[1]

[References]

[1]. Magrioti V, et al. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
330.3±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₅F₅O₂

[ Molecular Weight ]:
310.260

[ Flash Point ]:
148.5±22.8 °C

[ Exact Mass ]:
310.099213

[ LogP ]:
5.32

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.438