XEN723

Names

[ Name ]:
XEN723

Biological Activity

[Description]:

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD)

Research Areas >> Metabolic Disease

[Target]

IC50: 45 nM (SCD1 in Mouse), 524 nM (SCD1 in HepG2 cell)[1]

[In Vitro]

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit[1].

[References]

[1]. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.

[Related Small Molecules]

A939572 | PluriSln 1 | SCD inhibitor 1 | CAY 10566 | MK-8245 | CVT-12012

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₀FN₅O₂S

[ Molecular Weight ]:
425.48

[ Storage condition ]:
2-8℃