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PPC-NHS ester

Names

[ CAS No. ]:
107348-47-0

[ Name ]:
PPC-NHS ester

[Synonym ]:
MFCD28398150

Biological Activity

[Description]:

PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
468.8ºC at 760mmHg

[ Molecular Formula ]:
C13H14N2O4S2

[ Molecular Weight ]:
327.39900

[ Flash Point ]:
237.3ºC

[ Exact Mass ]:
327.04700

[ PSA ]:
131.35000

[ LogP ]:
0.54770

[ Vapour Pressure ]:
5.81E-09mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Storage condition ]:
-20°C


Related Compounds