RH 421

Names

[ Name ]:
RH 421

[Synonym ]:
MFCD00467839
Neurodye RH 421
RH 421
4-{4-[4-(Dipentylamino)phenyl]-1,3-butadienyl}-1-(4-sulfobutyl)pyridinium hydroxide

Biological Activity

[Description]:

RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. D Y Malkov, et al. Fluorescent styryl dyes of the RH series affect a potential drop on the membrane/solution boundary. Biochim Biophys Acta. 1996 Jan 31;1278(2):197-204.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₂N₂O₃S

[ Molecular Weight ]:
498.72000

[ Exact Mass ]:
498.29200

[ PSA ]:
72.70000

[ LogP ]:
7.29370

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore.

Biochim. Biophys. Acta 1848(1 Pt A) , 192-9, (2015)

The polyene antifungal antibiotic nystatin confers its biological activity by forming pores in the membranes of target cells. Exposure of only one side of the membrane to nystatin is more relevant tha...

[The effects of RH 421 on the activity of amphotericin B in cell and model membranes].

Tsitologiia 55(2) , 136-9, (2013)

The combined action of polyene macrolide antibiotic amphotericin B and styryl dye RH 421 in model lipid membranes and in yeast Saccharomyces cerevisiae has been studied. RH 421 insertion inti the ergo...

Probing amphotericin B single channel activity by membrane dipole modifiers.

PLoS ONE 7(1) , e30261, (2012)

The effects of dipole modifiers and their structural analogs on the single channel activity of amphotericin B in sterol-containing planar phosphocholine membranes are studied. It is shown that the add...