4-Phenoxybenzylamine

Names

[ Name ]:
4-Phenoxybenzylamine

[Synonym ]:
(4-Phenoxyphenyl)methanamine
MFCD01310836
Benzenemethanamine, 4-phenoxy-
1-(4-Phenoxyphenyl)methanamine

Biological Activity

[Description]:

4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

[Target]

IC50: 500 μM (FL NS3/4a)[1]

[In Vitro]

A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents[1].

[References]

[1]. Saalau-Bethell SM, et al. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol. 2012 Nov;8(11):920-5.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
319.6±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₃NO

[ Molecular Weight ]:
199.248

[ Flash Point ]:
149.5±16.4 °C

[ Exact Mass ]:
199.099716

[ PSA ]:
35.25000

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.595

Safety Information

[ Hazard Codes ]:
C: Corrosive;Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37/39

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%