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(rac)-PF-998425

Names

[ CAS No. ]:
1076225-26-7

[ Name ]:
(rac)-PF-998425

Biological Activity

[Description]:

(rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Androgen Receptor

[References]

[1]. Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7010-7014.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H14F3NO

[ Molecular Weight ]:
269.26

Related Compounds