Bulleyaconitine A

Names

[ Name ]:
Bulleyaconitine A

[Synonym ]:
(1α,6α,7β,14α,16β)-20-Ethyl-13-hydroxy-1,6,16-trimethoxy-14-(4-methoxybenzoyl)-4-(methoxymethyl)aconitan-8-yl acetate
BULLEYACONITINE A: METHANONE,[(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)
BULLEYACONITINE A(RG)
16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6
BulleyaconicineA
20-Ethyl-13-hydroxy-1,6,16-trimethoxy-14-(4-methoxybenzoyl)-4-(methoxymethyl)aconitan-8-yl acetate
Methanone, [8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-
Methanone, [(1α,6α,7β,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-
BULLEYACONITINE A(P)
METHANONE,[(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)
20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)

Biological Activity

[Description]:

Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

[References]

[1]. Wang CF, et al. Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg. 2008 Oct;107(4):1397-405.

[2]. Wang CF, et al. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Anesthesiology. 2007 Jul;107(1):82-90.

[3]. Weng WY, et al. A pharmacokinetic study of intramuscular administration of bulleyaconitine A in healthy volunteers. Biol Pharm Bull. 2005 Apr;28(4):747-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
690.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₅H₄₉NO₉

[ Molecular Weight ]:
627.765

[ Flash Point ]:
371.7±31.5 °C

[ Exact Mass ]:
627.340759

[ PSA ]:
112.99000

[ LogP ]:
1.05

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.590

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4932000

CHEMICAL NAME :: Methanone, ((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20- ethyl-13-hydroxy-1,6, 16- trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxy phenyl)-

CAS REGISTRY NUMBER :: 107668-79-1

LAST UPDATED :: 199503

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C35-H49-N-O9

MOLECULAR WEIGHT :: 627.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 510 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 28,378,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 28,378,1993

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330

[ Precautionary Statements ]:
P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 1544PSN1 6.1 / PGII