HZ52

Names

[ Name ]:
HZ52

[Synonym ]:
Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-
2-{[4-(4-Biphenylylamino)-6-chloro-2-pyrimidinyl]sulfanyl}octanoic acid

Biological Activity

[Description]:

HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[References]

[1]. Greiner C, et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164(2b):781-93.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
625.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₆ClN₃O₂S

[ Molecular Weight ]:
456.000

[ Flash Point ]:
332.0±31.5 °C

[ Exact Mass ]:
455.143433

[ PSA ]:
100.41000

[ LogP ]:
9.07

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.641

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

Functional p53 can modulate the relationship between E2F-1 expression and tumor kinetics in Hodgkin lymphoma.

Leuk. Lymphoma 56(3) , 748-54, (2015)

E2F-1 is the best-described member of the E2F family of transcriptional factors and is particularly interesting in view of its often opposing roles. Our purpose was to examine the immunohistochemical ...