DC_C66

Names

[ Name ]:
DC_C66

Biological Activity

[Description]:

DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

IC50: 1.8 μM (CARM1)[1]

[In Vitro]

DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: HELA, K562, MCF7 cells Concentration: 6.25, 12.5, 25, 50, 100 μM Incubation Time: 24, 48, 72 hours Result: Inhibits proliferation of cancer cells in a time-dependent and dose-dependent manner in HELA, K562, and MCF7 cells.

[References]

[1]. Ye F, et al. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. Biomed Res Int. 2016;2016:7086390.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₂NO₂+

[ Molecular Weight ]:
404.48

DC_C66

Names

Biological Activity

Chemical & Physical Properties

Related Compounds