Metallo β-lactamase ligand 1
Names
[ CAS No. ]:
1087784-71-1
[ Name ]:
Metallo β-lactamase ligand 1
Biological Activity
[Description]:
Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1].
[Related Catalog]:
[In Vitro]
One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent[1]. The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells[1].
[In Vivo]
After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C7H9NO5S
[ Molecular Weight ]:
219.22