Lin28-IN-1632

Names

[ Name ]:
Lin28-IN-1632

[Synonym ]:
Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]
N-Methyl-N-(3-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl)acetamide

Biological Activity

[Description]:

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Roos M, et al. A Small-Molecule Inhibitor of Lin28. ACS Chem Biol. 2016 Oct 21;11(10):2773-2781.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Melting Point ]:
200ºC

[ Molecular Formula ]:
C₁₅H₁₅N₅O

[ Molecular Weight ]:
281.31300

[ Exact Mass ]:
281.12800

[ PSA ]:
63.39000

[ LogP ]:
2.08240

[ Index of Refraction ]:
1.665

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S24/25

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%