methylpyrazine

Names

[ CAS No. ]:
109-08-0

[ Name ]:
methylpyrazine

[Synonym ]:
2-methyl-pyrazine
MFCD00006142
methylpyrazine
Pyrazine,2-methyl
2-Methylpyrazine
2-Methyl-1,4-diazine
Pyrazine, 2-methyl-
3-methylpyrazine
Pyrazine,methyl
EINECS 203-645-8

Biological Activity

[Description]:

2-Methylpyrazine is a kind of alkylpyrazine that can be identified in roasted red pepper seed oils[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. M Y Jung, et al. Effects of roasting on pyrazine contents and oxidative stability of red pepper seed oil prior to its extraction. J Agric Food Chem. 1999 Apr;47(4):1700-4.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
135.1±20.0 °C at 760 mmHg

[ Melting Point ]:
−29 °C(lit.)

[ Molecular Formula ]:
C₅H₆N₂

[ Molecular Weight ]:
94.115

[ Flash Point ]:
50.0±0.0 °C

[ Exact Mass ]:
94.053101

[ PSA ]:
25.78000

[ LogP ]:
0.18

[ Vapour Pressure ]:
9.7±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.503

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ3675000

CHEMICAL NAME :: Pyrazine, 2-methyl-

CAS REGISTRY NUMBER :: 109-08-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H6-N2

MOLECULAR WEIGHT :: 94.13

WISWESSER LINE NOTATION :: T6N DNJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 2500 mg/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,581,1980

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R10;R22

[ Safety Phrases ]:
S26-S36-S16

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
UQ3675000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Toward prediction of alkane/water partition coefficients.

J. Med. Chem. 51 , 3720-30, (2008)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the pa...

Orientation to determine quality attributes of flavoring excipients containing volatile molecules.

J. Pharm. Biomed. Anal. 110 , 20-6, (2015)

Pharmaceutical excipients containing volatile odor-active molecules can be used in pharmaceutical development to increase patients' compliance. However, capturing the molecular composition of these od...

Influence of Free Amino Acids, Oligopeptides, and Polypeptides on the Formation of Pyrazines in Maillard Model Systems.

J. Agric. Food Chem. 63 , 5364-72, (2015)

Pyrazines are specific Maillard reaction compounds known to contribute to the unique aroma of many products. Most studies concerning the generation of pyrazines in the Maillard reaction have focused o...