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SLF-amido-C2-COOH

Names

[ CAS No. ]:
1092369-24-8

[ Name ]:
SLF-amido-C2-COOH

Biological Activity

[Description]:

Target Protein-binding moiety 13 is a synthetic ligand for FKBP (SLF), which is used in the synthesis of PROTACs.

[Related Catalog]:

Signaling Pathways >> PROTAC >> PROTAC
Research Areas >> Cancer

[In Vitro]

Target Protein-binding moiety 13 (SLF building block 2) is a synthetic ligand for FKBP (SLF). SLF is composed of only one half of FK506 and it is known to have a significantly weaker affinity for FKBP12.

[References]

[1]. Dunyak BM, et al. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of TwoIntracellular Proteins. ACS Chem Biol. 2015 Nov 20;10(11):2441-7.


[Related Small Molecules]

ARV-771 | ARV-825 | dBET1 | Protein degrader 1 hydrochloride | dBET6 | Mz1 | BETd-260 | VH032-PEG5-C6-Cl (HaloPROTAC 2) | PROTAC 6 | Target Protein-binding moiety 4 | dTRIM24 | MZP-54 | PROTAC BET degrader-2

Chemical & Physical Properties

[ Molecular Formula ]:
C34H44N2O9

[ Molecular Weight ]:
624.72

[ Storage condition ]:
-20°C

Related Compounds