Biotin LC hydrazide

Names

[ CAS No. ]:
109276-34-8

[ Name ]:
Biotin LC hydrazide

[Synonym ]:
biotinamidocaproyl hydrazide
MFCD00077659
Biotin LC hydrazide

Biological Activity

[Description]:

Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Others

[In Vitro]

Biotin LC hydrazide (BACH) is often used to target glycoproteins and glycans. It is carbohydrate reactive and is more sensitive than biotin hydrazide[1]. A new biotinylating system for DNA using Biotin LC hydrazide (biotin aminocaproyl hydrazide) and glutaraldehyde[2].

[References]

[1]. O'Shannessy DJ, et al. Quantitation of glycoproteins on electroblots using the biotin-streptavidin complex. Anal Biochem. 1987 May 15;163(1):204-9.

[2]. Takahashi T, et al. A new biotinylating system for DNA using biotin aminocaproyl hydrazide and glutaraldehyde. Nucleic Acids Res. 1989 Jun 26;17(12):4899-900.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.188 g/cm3

[ Boiling Point ]:
777ºC at 760 mmHg

[ Melting Point ]:
195-196°C

[ Molecular Formula ]:
C₁₆H₂₉N₅O₃S

[ Molecular Weight ]:
371.49800

[ Flash Point ]:
423.7ºC

[ Exact Mass ]:
371.19900

[ PSA ]:
150.65000

[ LogP ]:
2.51840

[ Vapour Pressure ]:
4.43E-24mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 25 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

Articles

Quantitation of glycoproteins on electroblots using the biotin-streptavidin complex.

Anal. Biochem. 163 , 204, (1987)

A method for the detection and quantitation of glycoproteins on nitrocellulose electroblots is described. Protein mixtures may be solubilized in sodium dodecyl sulfate prior to labeling, which is espe...

Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites.

J. Med. Chem. 57(11) , 4521-31, (2014)

Atg8 is a ubiquitin-like autophagy protein in eukaryotes that is covalently attached (lipidated) to the elongating autophagosomal membrane. Autophagy is increasingly appreciated as a target in diverse...

Receptor binding activities of biotinylated derivatives of beta-nerve growth factor.

J. Neurochem. 46 , 641-648, (1986)

beta-nerve growth factor (NGF) was modified by biotinylation via carboxyl group substitution (C-bio-NGF) using biotin hydrazide and the coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide,...