(D-Arg0,Hyp3,D-Phe7)-Bradykinin trifluoroacetate salt

Names

[ Name ]:
(D-Arg0,Hyp3,D-Phe7)-Bradykinin trifluoroacetate salt

[Synonym ]:
(D-ARG0,HYP3,D-PHE7)-BRADYKININ
D-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-D-Arg-OH
D-ARG-ARG-PRO-HYDROXY-PRO-GLY-PHE-SER-D-PHE-PHE-ARG
D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG
D-Phe7]-bradykinin
D-Arg-Arg-Pro-Hyp-Gly-Phe-Phe-Arg
(D-Arg0,Hyp3,D-Phe7)bradikinin
D-Arg[Hyp3,D-Phe7]-bradykinin
D-Arg-Arg-Pro-t4Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH
L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-
npc567
D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-L-Arg-OH
D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-L-arginine
H-D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG-OH

Biological Activity

[Description]:

NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

[References]

[1]. Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72.

[2]. Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₆₀H₈₇N₁₉O₁₃

[ Molecular Weight ]:
1282.45

[ Exact Mass ]:
1281.673096

[ PSA ]:
533.80000

[ LogP ]:
-2.56

[ Index of Refraction ]:
1.691

Safety Information

[ WGK Germany ]:
3