Ms-PEG6-Ms

Names

[ Name ]:
Ms-PEG6-Ms

[Synonym ]:
3,6,9,12,15-Pentaoxaheptadecane-1,17-diol,dimethanesulfonate
hexaethylene glycol bis(methanesulfonate)
PEG6-di-OMs
methanesulfonic acid 2-[2-(2-{2-[2-(2-methanesulfonyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl ester
hexaethylene glycol bismesylate
hexaethylene glycol dimesylate
hexaethylene glycol dimethanesulfonate
Ms-PEG6-Ms

Biological Activity

[Description]:

Ms-PEG6-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₃₄O₁₃S₂

[ Molecular Weight ]:
474.54200

[ Exact Mass ]:
474.14400

[ PSA ]:
212.11000

[ LogP ]:
0.22360

Ms-PEG6-Ms

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds