Boc-DADdec

Names

[ Name ]:
Boc-DADdec

[Synonym ]:
Boc-DADdec
TERT-BUTYL 12-AMINODODECYLCARBAMATE
N-Boc-1,12-dodecanediamine
N-t-Butyloxycarbonyl-1,12-diaminododecane
N-tert-butoxycarbonyl-1,12-diaminododecane
1,12-Diaminododecane,N-BOC protected
tert-butyl 2,13-diaMinotridecanoate
mono-tert-butoxycarbonyl-1,12-diaminododecane

Biological Activity

[Description]:

Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
0.924g/cm3

[ Boiling Point ]:
409.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₃₆N₂O₂

[ Molecular Weight ]:
300.48000

[ Flash Point ]:
201.3ºC

[ Exact Mass ]:
300.27800

[ PSA ]:
64.35000

[ LogP ]:
5.46200

[ Vapour Pressure ]:
6.61E-07mmHg at 25°C

[ Index of Refraction ]:
1.463

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%