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Pyrithioxin

Names

[ CAS No. ]:
1098-97-1

[ Name ]:
Pyrithioxin

[Synonym ]:
Epocan
Dipyridoxolyldisulfide
Pyrithioxine
MFCD00151477
Bonifen
Piritinol
Pyridoxine disulfide
Bonol
PYRITINOL
Encefabol
Pyrithioxin
EINECS 214-150-1

Biological Activity

[Description]:

Pyrithioxin is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Stoica E, et al. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. Eur Neurol. 1975;13(4):285-303.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.448 g/cm3

[ Boiling Point ]:
742.8ºC at 760 mmHg

[ Melting Point ]:
54-57 °C(lit.)

[ Molecular Formula ]:
C16H20N2O4S2

[ Molecular Weight ]:
368.47100

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
368.08600

[ PSA ]:
157.30000

[ LogP ]:
2.57080

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT4836666
CHEMICAL NAME :
4-Pyridinemethanol, 3,3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl-
CAS REGISTRY NUMBER :
1098-97-1
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H20-N2-O4-S2
MOLECULAR WEIGHT :
368.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4598079

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
UT4836666

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[The use of encephabol in neurological practice].

Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 102(6) , 53-6, (2002)

Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride.

Drug Test. Anal. 1(5) , 228-33, (2009)

Three multivariate calibration methods, including classical least square with nonzero intercept (CLS), principal component regression (PCR) and partial least square (PLS), have been used for the deter...

Pyritinol reduces nociception and oxidative stress in diabetic rats

Eur. J. Pharmacol. 590(1-3) , 170-6, (2008)

The purpose of this study was to assess the antinociceptive and antiallodynic effect of pyritinol as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 mg/kg) injection caus...


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Related Compounds