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Procaspase-3 activator 1541

Names

[ CAS No. ]:
1100353-03-4

[ Name ]:
Procaspase-3 activator 1541

[Synonym ]:
Procaspase-3 activator 1541

Biological Activity

[Description]:

Procaspase-3/6 activator 1 (compound 1541) is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Procaspase-3/6 activator 1 does not activate procaspases-1 or -7[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Apoptosis >> Caspase

[Target]

Procaspase-3:2.4 ± 0.2 μM (EC50)

Procaspase-6:2.8 ± 0.3 μM (EC50)


[References]

[1]. Wolan DW, et al. Small-molecule activators of a proenzyme. Science. 2009 Nov 6;326(5954):853-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H17N3O4

[ Molecular Weight ]:
411.41

[ Exact Mass ]:
411.12200

[ PSA ]:
85.84000

[ LogP ]:
4.44160

[ Storage condition ]:
2-8°C

Related Compounds