Calpain Inhibitor I

Names

[ Name ]:
Calpain Inhibitor I

[Synonym ]:
N-Acetyl-L-leucyl-N-[(2S)-1-oxohexan-2-yl]-L-leucinamide
ALLN Ac-LLnL-CHO MG-101 N-Acetyl-Leu-Leu-Norleu-al N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
Ac-Leu-Leu-Nle-H
AC-LL-NORLEUCINAL
AC-LEU-LEU-NORLEUCINAL
Ac-Leu-Leu-Nle-al
Calpain Inhibitor I,ALLN
CALPAIN INHIBITOR I
MG 101
ALLN
N-Acetyl-L-leucyl-N-((1S)-1-formylpentyl)-L-leucinamide
ac-llnl-cho
AC-LEU-LEU-NLE-CHO
acetylleucyl-leucyl-norleucinal
N-Acetyl-L-leucyl-N-[(2S)-1-oxo-2-hexanyl]-L-leucinamide
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-
LLNL
CALPAIN INHIBITOR
MFCD00065505

Biological Activity

[Description]:

MG-101 is a potent inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

Research Areas >> Cancer

[References]

[1]. Li SZ, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437(2):325-330.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
632.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₇N₃O₄

[ Molecular Weight ]:
383.526

[ Flash Point ]:
192.9±30.3 °C

[ Exact Mass ]:
383.278412

[ PSA ]:
104.37000

[ LogP ]:
3.37

[ Appearance of Characters ]:
powder | white

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.474

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: soluble | Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

PLoS ONE 10(3) , e0119423, (2015)

Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In...

The role of proteases in excitation-contraction coupling failure in muscular dystrophy.

Am. J. Physiol. Cell Physiol. 308(1) , C33-40, (2015)

Duchenne muscular dystrophy (DMD) is one of the most frequent types of muscular dystrophy. Alterations in intracellular calcium (Ca(2+)) handling are thought to contribute to the disease severity in D...

Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.

Cell Death Dis. 6 , e1769, (2015)

Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregu...