Concanavalin A

Names

[ Name ]:
Concanavalin A

[Synonym ]:
EINECS 234-258-2
MFCD00071069

Biological Activity

[Description]:

Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[References]

[1]. Li W, et, al. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem Biophys Res Commun. 2011 Oct 22;414(2):282-6.

[2]. Cantelli A, et, al. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₄

[ Molecular Weight ]:
304.35

[ Flash Point ]:
39 °C

[ Appearance of Characters ]:
powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
PBS: 5 mg/mL, slightly hazy | Slightly soluble in water and phosfate buffered saline.

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334-H361

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S36;S24/25

[ RIDADR ]:
UN 1170 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
GK6890000

[ HS Code ]:
35040090

Articles

The second virial coefficient as a predictor of protein aggregation propensity: A self-interaction chromatography study.

Eur. J. Pharm. Biopharm. 96 , 282-90, (2015)

The second osmotic virial coefficients (b2) of four proteins - lysozyme, recombinant human lactoferrin, concanavalin A and catalase were measured by self-interaction chromatography (SIC) in solutions ...

Osmolyte effects on the self-association of concanavalin A: testing theoretical models.

Biochemistry 52(51) , 9367-74, (2013)

The formation and stability of protein-protein interfaces are of obvious biological importance. While a large body of literature exists describing the effect of osmolytes on protein folding, very few ...

Cellular interaction of nontypeable Haemophilus influenzae triggers cytotoxicity of infected type II alveolar cells via apoptosis.

Pathog. Dis. 73(2) , 1-12, (2015)

Nontypeable Haemophilus influenzae (NTHi) is an important cause of lower respiratory tract infections, resulting in exacerbations of chronic obstructive pulmonary disease (COPD). Despite its pathogeni...