taxamairin B

Names

[ Name ]:
taxamairin B

[Synonym ]:
Taxamairin B
1H-Dibenzo(a,d)cycloheptene-2,10-dione,6,7-dimethoxy-1,1-dimethyl-8-(1-methylethyl)

Biological Activity

[Description]:

Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significantprotective effects in LPS-induced acute lung injury in mice[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Research Areas >> Inflammation/Immunology

[References]

[1]. Liu M, et al. Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-κB axis in macrophages. Eur J Med Chem. 2023 Nov 15;260:115769.

[2]. Liang JY, et al. Two new antineoplastic diterpenes from Taxus mairei. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2613-4.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
577.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₄O₄

[ Molecular Weight ]:
352.42400

[ Flash Point ]:
252.7ºC

[ Exact Mass ]:
352.16700

[ PSA ]:
52.60000

[ LogP ]:
4.21410

[ Vapour Pressure ]:
2.48E-13mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ HS Code ]:
2914509090

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%