Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

Names

[ Name ]:
Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

[Synonym ]:
Coformycin

Biological Activity

[Description]:

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase

Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc[2]. Animal Model: Swiss-Webster mice[2]. Dosage: 0.2 mg/kg. Administration: IP daily. Result: Inhibited adenosine deaminase activity for various tissues.

[References]

[1]. Coformycin.

[2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.

Chemical & Physical Properties

[ Density]:
1.96g/cm3

[ Boiling Point ]:
692.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₆N₄O₅

[ Molecular Weight ]:
284.26900

[ Flash Point ]:
372.7ºC

[ Exact Mass ]:
284.11200

[ PSA ]:
132.36000

[ Vapour Pressure ]:
3.84E-20mmHg at 25°C

[ Index of Refraction ]:
1.828

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI2931500

CHEMICAL NAME :: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-

CAS REGISTRY NUMBER :: 11033-22-0

LAST UPDATED :: 198311

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H16-N4-O5

MOLECULAR WEIGHT :: 284.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,330,1981