Ch 55

Names

[ Name ]:
Ch 55

[Synonym ]:
3,5-di-tert-butylchalcone 4'-carboxylic acid
CH 55
3,5-Di-tert-butylchalcone

Biological Activity

[Description]:

Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RARα

RARβ

[In Vitro]

Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1].

[References]

[1]. Jetten AM, et al. New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein. Cancer Res. 1987 Jul 1;47(13):3523-7.

[2]. Takahashi N, et al. Induction of differentiation and covalent binding to proteins by the synthetic retinoids Ch55 and Am80. Arch Biochem Biophys. 1994 Oct;314(1):82-9.

Chemical & Physical Properties

[ Density]:
1.085g/cm3

[ Boiling Point ]:
509.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₂₈O₃

[ Molecular Weight ]:
364.47700

[ Flash Point ]:
276ºC

[ Exact Mass ]:
364.20400

[ PSA ]:
54.37000

[ LogP ]:
5.87590

[ Vapour Pressure ]:
3.33E-11mmHg at 25°C

[ Index of Refraction ]:
1.574

Safety Information

[ HS Code ]:
2918300090

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%