N6-(4-Hydroxybenzyl)adenosine

Names

[ Name ]:
N6-(4-Hydroxybenzyl)adenosine

[Synonym ]:
N6-(4-Hydroxybenzyl)-adenosine
Adenosine,N-[(4-hydroxyphenyl)methyl]
N6-(4-hydroxybenzyl)adenine riboside
N6-(4-Hydroxybenzyl)adenosine

Biological Activity

[Description]:

N6-(4-Hydroxybenzyl)adenosine is a inhibitor of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). IC50 value: 6.77-141 μMTarget: P2Y12receptorAnti-aggregation activity of N6-(4-Hydroxybenzyl)adenosine could involve an interaction with the P2Y12receptor binding site.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

Research Areas >> Cardiovascular Disease

[References]

[1]. Vistoli G, et al. Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5652-

[2]. Zhang, Ying; Shi, Jian-gong; Liu, Geng-tao; Zhang, Jian-jun. Effect of N6-(4-hydroxybenzyl) adenine riboside isolated from Gastrodia elata on muscle strength, motor coordination and body temperature in mice. From Guoji Yaoxue Yanjiu Zazhi (2012), 39(5), 4

[Related Small Molecules]

Suramin sodium | MRS 2578 | Diquafosol Tetrasodium | Prasugrel | BPTU | AZD 1283 | TAK-024

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₉N₅O₅

[ Molecular Weight ]:
373.36300

[ Exact Mass ]:
373.13900

[ PSA ]:
145.78000

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%