Insulin(human)

Names

[ Name ]:
Insulin(human)

[Synonym ]:
MFCD00131380
Oral-lyn
Penfil R
Ultraphane
EINECS 234-279-7
Umulin
Velosulin HM
ORMD 0801
Insulin(human)

Biological Activity

[Description]:

Insulin(human) is a peptide hormone that regulates the level of sugar (glucose) in the blood and that is produced by the beta cells of the pancreatic islets.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor

Research Areas >> Metabolic Disease

Peptides

[In Vitro]

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region[1]. Human insulin is commonly used to treat type 2 diabetes[2].

[References]

[1]. Bell GI, et al. Sequence of the human insulin gene. Nature. 1980 Mar 6;284(5751):26-32.

[2]. Tseng CH, et al. Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes. BMC Cancer. 2015 Nov 4;15:846.

[Related Small Molecules]

OSI-906(Linsitinib) | Insulin(cattle) | BMS-754807 | NVP-AEW541 | BMS-536924 | NT157 | GSK1838705A | CAY10415 | AGL-2263 | KU14R | Insulin levels modulator | Kaempferitrin

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅₇H₃₈₃N₆₅O₇₇S₆

[ Molecular Weight ]:
5807.58

[ Appearance of Characters ]:
Solution

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble up to 10mg/ml in pH <3 or in the presence of surfactants. Adjusting pH with a volatile acid (such as formic acid) prior to dry down will allow the product to be re-dissolved in water.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NM8900250

Articles

Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes.

Skelet. Muscle 5 , 26, (2015)

In skeletal muscle, intracellular Ca(2+) is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, ...

LipiD-QuanT: a novel method to quantify lipid accumulation in live cells.

J. Lipid Res. 56 , 2206-16, (2015)

Lipid droplets (LDs) are the main storage organelles for triglycerides. Elucidation of lipid accumulation mechanisms and metabolism are essential to understand obesity and associated diseases. Adipoge...

Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification.

Nat. Commun. 6 , 7007, (2015)

The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidifi...