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Wilforine

Names

[ CAS No. ]:
11088-09-8

[ Name ]:
Wilforine

[Synonym ]:
(1S,3R,15S,18S,19R,20R,21R,22S,23R,24R,25R,26S)-20,22,23,25-Tetraacetoxy-21-(acetoxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.0.0.0]hexaco sa-7,9,11-trien-19-yl benzoate
20,22,23,25-Tetraacetoxy-21-(acetoxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.0.0.0]hexacosa-7,9,11-trien-19-yl benzoate
26-Deoxywilfordine

Biological Activity

[Description]:

Wilforine is a sesquiterpene pyridine alkaloid; importantbioactive compound in T. wilfordii plants, and is effective intreating idiopathic pulmonary fibrosis.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Natural Products >> Alkaloid
Research Areas >> Others

[References]

[1]. Zhu C, et al. Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine. J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34.

[2]. Miao GP, et al. Elicitation and in situ adsorption enhanced secondary metabolites production of Tripterygium wilfordii Hook. f. adventitious root fragment liquid cultures in shake flask and a modified bubble column bioreactor. Bioprocess Biosyst Eng. 2014


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
871.5±65.0 °C at 760 mmHg

[ Melting Point ]:
158-163ºC

[ Molecular Formula ]:
C43H49NO18

[ Molecular Weight ]:
867.845

[ Flash Point ]:
480.9±34.3 °C

[ Exact Mass ]:
867.294983

[ PSA ]:
252.75000

[ LogP ]:
6.24

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.589

[ Storage condition ]:
2-8℃

Related Compounds