ir-797 chloride

Names

[ Name ]:
ir-797 chloride

[Synonym ]:
2-[2-[2-chloro-3-[2-(1,3-dihydro-1,3,3-trimethyl-2h-indol-2-ylidene)-ethylidene]-1-cyclopenten-1-yl-ethenyl]-1,3,3-trimethyl-3h-indolium chloride

Biological Activity

[Description]:

IR-797 chloride is a near-infrared (NIR) dye. IR 797 has absorption maxima near 700 nm. IR-797 shows some aggregation-induced-emission (AIE) properties. IR-797 shows shows cytotoxic[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

The hydrophobic IR-797 molecules are self-assembled into nanoparticles, which are further modified with an amphiphilic polymer (C18PMH-PEG5000) on the surface[1]. IR-797 can be used to make PEG-IR-797 nanoparticles and work as a chemotherapeutic drug which induces apoptosis of cancer cells[1].

[References]

[1]. Xiao YF, et al. The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics. Small. 2019 Sep;15(38):e1903121.

[2]. Fan Cao, et al. Wavelength-Dependent Tip-Enhanced Laser Ablation of Organic Dyes. The Journal of Physical Chemistry C. 2020, 124, 3, 1918–1922

Chemical & Physical Properties

[ Melting Point ]:
116.7-128.0ºC(lit.)

[ Molecular Formula ]:
C₃₁H₃₄Cl₂N₂

[ Molecular Weight ]:
505.52100

[ Exact Mass ]:
504.21000

[ PSA ]:
6.25000

[ LogP ]:
4.80120

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport