Guancydine

Names

[ Name ]:
Guancydine

[Synonym ]:
tert.-Amyldicyandiamid
Guancydine
EINECS 263-799-7
EINECS 214-198-3
Guancidine
1-Cyano-3-t-pentylguanidine
Guancydine [USAN]
Guancidinum [INN-Latin]
1-Cyano-3-tert-amylguanidine
Guancidina [INN-Spanish]

Biological Activity

[Description]:

Guancydine (Guancidine) is an antihypertensive agent[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Clark DW, et al. Guancydine: a new antihypertensive agent. Use with quinethazone and guanethidine or propranolol. Ann Intern Med. 1972 Apr;76(4):579-85.

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
239.3ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₁₄N₄

[ Molecular Weight ]:
154.21

[ Flash Point ]:
98.5ºC

[ Exact Mass ]:
154.12200

[ PSA ]:
71.70000

[ LogP ]:
1.65158

[ Vapour Pressure ]:
0.0404mmHg at 25°C

[ Index of Refraction ]:
1.504

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF0175000

CHEMICAL NAME :: Guanidine, 1-cyano-3-tert-pentyl-

CAS REGISTRY NUMBER :: 1113-10-6

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H14-N4

MOLECULAR WEIGHT :: 154.25

WISWESSER LINE NOTATION :: NCMYUM&MX2&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 313 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 322 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

Safety Information

[ HS Code ]:
2926909090

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%