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Androgen receptor modulators 1

Names

[ CAS No. ]:
1114546-03-0

[ Name ]:
Androgen receptor modulators 1

Biological Activity

[Description]:

Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Androgen Receptor

[Target]

EC50: 4.7 nM (SARM)[1]


[In Vitro]

Androgen receptor modulators 1 (Compounds 2f) induces sexual behavior at the minimal dose (0.5 mg/kg/day, qd, po). It could act as androgen agonist on the CNS[1]. Androgen receptor modulators 1 shows good metabolic stabilities with little species difference between rat, dog, mouse, monkey and human[1].

[References]

[1]. Aikawa K, et al. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg Med Chem. 2017 Jul 1;25(13):3330-3349.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H13F3N2O2

[ Molecular Weight ]:
298.26

Related Compounds