<Suppliers Price>

UCD38B HCl

Names

[ CAS No. ]:
1115177-19-9

[ Name ]:
UCD38B HCl

[Synonym ]:
UCD38B hydrochloride
Carbamic acid, N-[[6-amino-5-[[(aminoiminomethyl)amino]carbonyl]-3-chloro-2-pyrazinyl]methyl]-, phenylmethyl ester, hydrochloride (1:1)
5'-Benzylglycinyl-amiloride
Benzyl {[6-amino-5-(carbamimidoylcarbamoyl)-3-chloro-2-pyrazinyl]methyl}carbamate hydrochloride (1:1)
N-[6-Amino-5-[[(aminoiminomethyl)amino]carbonyl]-3-chloro-2-pyrazinyl]-glycine phenylmethyl ester hydrochloride

Biological Activity

[Description]:

UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

UCD38B hydrochloride (10-250 μM; 1h) has cell permeant in U87MG cells[1]. UCD38B hydrochloride (10-250 μM; 1h) inhibits cell growth with an IC50 value of 100 μM[1]. Cell Viability Assay[1] Cell Line: U87MG cells Concentration: 10, 100, and 250 μM Incubation Time: 24 hours Result: Inhibited cell growth in a dose-dependent manner.

[References]

[1]. Pasupuleti N, et, al. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15.  

[2]. Leon LJ, et, al. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8(4):e63038.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H17Cl2N7O3

[ Molecular Weight ]:
414.247

[ Exact Mass ]:
413.076996

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds