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Ochromycinone

Names

[ CAS No. ]:
111540-00-2

[ Name ]:
Ochromycinone

[Synonym ]:
ochromycinone
STA-021
Ochromycinon, 8-Hydroxy-3-methyl-1-oxo-1,2,3,4-tetrahydrobenz(a)anthrachinon
Ochromycinon, 8-Hydroxy-3-methyl-1-oxo-1,2,3,4-tetrahydrobenz[a]anthrachinon
STA-21

Biological Activity

[Description]:

Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

STAT3


[In Vitro]

STA-21 inhibits STAT3 DNA binding activity, STAT3 dimerization, and STAT3-dependent luciferase activity. Moreover, STA-21 reduces the survival of breast carcinoma cells with constitutive STAT3 signaling but has minimal effect on the cells in which constitutive STAT3 signaling is absent[2].

[References]

[1]. Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5.

[2]. Nataliya I. Kalinovskaya, et al. New Angucyclinones from the Marine Mollusk Associated Actinomycete Saccharothrix espanaensis An 113. Natural product communications. 2008, 3(10):1611-1616.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14O4

[ Molecular Weight ]:
306.31200

[ Exact Mass ]:
306.08900

[ PSA ]:
71.44000

[ LogP ]:
2.93260

[ Storage condition ]:
-20℃

Related Compounds