NALTRIBEN MESYLATE

Names

[ Name ]:
NALTRIBEN MESYLATE

[Synonym ]:
naltrindole benzofuran
C26H25NO4
NTB
HMS2089G18

Biological Activity

[Description]:

Naltriben is a selective δ2-opioid receptor antagonist and TRPM7 activator. Naltriben enhances glioblastoma cell migration and invasion. Naltriben can be used in research into neurological diseases and cancer[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

[References]

[1]. Lever JR, et al. Selective in vivo binding of [3H]naltriben to delta-opioid receptors in mouse brain. Eur J Pharmacol. 1998 Jun 5;350(2-3):335-44.

[2]. Wong R, et al. Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells. Oncotarget. 2017 Feb 14;8(7):11239-11248.

Chemical & Physical Properties

[ Density]:
1.5 g/cm3

[ Boiling Point ]:
605.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₅NO₄

[ Molecular Weight ]:
415.48

[ Flash Point ]:
319.9ºC

[ Exact Mass ]:
511.16600

[ PSA ]:
128.82000

[ LogP ]:
4.36020

[ Vapour Pressure ]:
1.67E-15mmHg at 25°C

[ Index of Refraction ]:
1.779

NALTRIBEN MESYLATE

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds