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Bexagliflozin

Names

[ CAS No. ]:
1118567-05-7

[ Name ]:
Bexagliflozin

[Synonym ]:
THR-1442
(1S)-1,5-Anhydro-1-(4-chloro-3-{4-[2-(cyclopropyloxy)ethoxy]benzyl}phenyl)-D-glucitol
EGT0001442
UNII:EY00JF42FV
THR1442
bexagliflozin
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)-
EGT1442

Biological Activity

[Description]:

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.target: SGLT2IC50: 5.6 μM (SGLT1)/ 2 nM (SGLT2)1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively.2) EGT1442 significantly prolonged the median survival of SHRSP rats.3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT
Research Areas >> Metabolic Disease

[References]

[1]. Zhang W et al. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. Pharmacol Res. 2011 Apr;63(4):284-93.


[Related Small Molecules]

Phlorizin | Phloretin | LX-4211 | Ertugliflozin | Licogliflozin | Tofogliflozin (hydrate) | Ipragliflozin | Velagliflozin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
671.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H29ClO7

[ Molecular Weight ]:
464.936

[ Flash Point ]:
359.6±31.5 °C

[ Exact Mass ]:
464.160187

[ PSA ]:
108.61000

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Storage condition ]:
2-8℃

Related Compounds