1,2,4-Triazin-3-amine

Names

[ Name ]:
1,2,4-Triazin-3-amine

[Synonym ]:
1,2,4]TRIAZIN-3-YLAMINE
3-Amino-1,2,4-Triazine
3-AMINO-1 2 4-TRIAZINE
EINECS 214-324-7
1,2,4-TRIAZINE-3-AMINE
1,2,4-Triazin-3-amine
1,2,4-TRIAZIN-3-AMIN
MFCD00006459
1,2,4-triazine-3-ylamine

Biological Activity

[Description]:

3-Amino-1,2,4-triazine is an inhibitor of NO synthase, and also inhibits nitrite secretion[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[In Vitro]

3-Amino-1,2,4-triazine (50 mM; 7 h) inhibits NO synthase activity in cytosolic extracts of activated cells[1]. 3-Amino-1,2,4-triazine (5-50 mM; 24 h) inhibits both nitrite secretion and parasite killing by activated macrophages[1].

Chemical & Physical Properties

[ Density]:
1.346g/cm3

[ Boiling Point ]:
311.7ºC at 760mmHg

[ Melting Point ]:
174-177 °C(lit.)

[ Molecular Formula ]:
C₃H₄N₄

[ Molecular Weight ]:
96.09070

[ Flash Point ]:
168ºC

[ Exact Mass ]:
96.04360

[ PSA ]:
64.69000

[ LogP ]:
0.03500

[ Vapour Pressure ]:
0.000553mmHg at 25°C

[ Index of Refraction ]:
1.61

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY2969000

CHEMICAL NAME :: as-Triazine, 3-amino-

CAS REGISTRY NUMBER :: 1120-99-6

LAST UPDATED :: 199309

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C3-H4-N4

MOLECULAR WEIGHT :: 96.11

WISWESSER LINE NOTATION :: T6NN DNJ CZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 95,123,1953

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ WGK Germany ]:
3

[ RTECS ]:
XY2969000

[ HS Code ]:
2933699090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933699090

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%