Br-Boc-C2-azido

Names

[ CAS No. ]:
1120364-53-5

[ Name ]:
Br-Boc-C2-azido

[Synonym ]:
MFCD28144595

Biological Activity

[Description]:

Br-Boc-C2-azido is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₀BrN₃O₂

[ Molecular Weight ]:
236.07

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Articles

General Approach to Individually Dispersed, Highly Soluble, and Conductive Graphene Nanosheets Functionalized by Nitrene Chemistry Hongkun He, Chao Gao

Chem. Mater. 22(17) , 5054-5064, (2010)

Click chemistry as a route for the immobilization of well-defined polystyrene onto sheets Shengtong Sun, Yewen Cao, Jiachun Feng; et al.

J. Mater. Chem. 20(27) , 5605-5607, (2010)