3-Hydroxy-2-Methylpyridine

Names

[ Name ]:
3-Hydroxy-2-Methylpyridine

[Synonym ]:
3-Hydroxy-2-methylpyridine
3-Pyridinol, 2-methyl-
EINECS 214-327-3
Pyridyl-3-methanol
2-Methyl-3-pyridinol
2-methyl-3-hydroxypyridine
2-methylpyridin-3-ol
MFCD00082538

Biological Activity

[Description]:

3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Gottfried Ziegleder, et al. Composition of flavor extracts of raw and roasted cocoas. Zeitschrift für Lebensmittel-Untersuchung und Forschung volume 192, pages521–525(1991).

[2]. S M Bromidge, et al. 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1863-6.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
287.1±20.0 °C at 760 mmHg

[ Melting Point ]:
168-169 °C(lit.)

[ Molecular Formula ]:
C₆H₇NO

[ Molecular Weight ]:
109.126

[ Flash Point ]:
127.4±21.8 °C

[ Exact Mass ]:
109.052765

[ PSA ]:
33.12000

[ LogP ]:
1.10

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38;R41

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response.

Clin. Chem. 49(3) , 515-8, (2003)

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.

Bioorg. Med. Chem. Lett. 10(16) , 1863-6, (2000)

Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally media...